MATSUI Hideaki

Associate Professor

Contact Info

Address
Brain Research Institute,
Niigata University 1-757 Asahimachidori, Chuo-ku Niigata 951-8585
Phone
+81-(0)25-227-2922
E-mail
hide0729@bri.niigata-u.ac.jp
Related Link
Department of Neuroscience of Disease (English)

Research Areas

Neuroscience, Neurology

Keywords

small fish, neurodegenerative disorder, synapse

Research Description

There exist approximately 100,000,000,000 neurons in each human brain, and the number of glia cells is much more than that of neurons. Supposed that each neuron is a star in the Universe, we could compare the brain to a small Universe within. However things are more complicated because each neuron extends long fibers to other neurons for communicating signals. In one sense, the brain, a small Universe, is much more complicated than the Universe itself. It is theoretically, technically and physically impossible to study all the twinkling stars in the sky. But we could estimate the characters of stars or planets by carefully observing and analyzing the sun and planets in the solar system. It is also impossible to elucidate functions, anatomies and networks of all the neurons one by one, but we are able to reach a right conclusion if we handle a miniature brain and deduce common principles from the mini-brain.

This is the way that we have followed. We will disclose the phenomenon occurring in human brain by studying Fish brain. Especially our aim is to elucidate the mechanism of neurological diseases and disorders, deepening scientific and social understanding for some, or finding a drug for others. We human beings have evolved exactly from Fish. It is true that there exist human specific structures, but most of the functions and structures in the human brain are preserved in Fish brain. Furthermore we could replicate human neurological diseases in the miniature brain of the Fish. Our laboratory has tried uncovering the physiological functions and pathophysiology of the brain using Fish brains, and we will surely find therapies for neurological diseases and disorders.

Academic Affiliation

  • Japanese Society of Neurology.
  • The Japan Neuroscience Society.
  • The Molecular Biology Society of Japan.
  • The Japanese Society of Internal Medicine.

Education

Completed Department of Neurology, Kyoto University Graduate School of Medicine Apr 2006 – Mar 2010

Careers

2001–2002 Kyoto University Hospital / Intern
2002–2006 Department of Neurology after Department of General Medicine ,Sumitomo Hospital
(received certification as member of the Japanese Society of Internal Medicine in
September 2004) / Internist Neurologist
2011–2012 TU Braunschweig, Zoological Institute, Division of Cell Physiology
(Humboldt Research Fellowship) / Postdoctoral Fellow
2013–2013 Department of Neuroscience, Section of Integrative Physiology,
Faculty of Medicine, Graduate School of Medicine, University of Miyazaki / Postdoctoral Fellow
2014–2016 Department of Neuroscience, Section of Integrative Physiology,
Faculty of Medicine, Graduate School of Medicine, University of Miyazaki / Assistant Professor
2016–Present Niigata University Department of Neuroscience Disease,
Center for Transdisciplinary Research (Brain Research Lab) / Associate Professor

Grants and Fellowships

2015 The Sumitomo Foundation
2015 Glaxo Smith Kline Research Grant
2015 Public Health Research Foundation
2014~2016 Grant-in-Aid for Young Scientists (A)
2014 Brain Science Foundation
2013 Japan Instractable Diseases Research Foundation
2013 The Yokoyama Foundation for Clinical Pharmacology
2013 The Takeda Science Foundation
2013~2014 Grant-in-Aid for Challenging Exploratory Research
2012 The Tokyo Biochemical Research Foundation
2012 The Uehara Memorial Foundation
2012 The Shimabara Science Foundation
2012 Grant-in-Aid for Young Scientists (Start-Up)
2012 The Takeda Science Foundation

Selected Recent Publications

  • Matsui, H., Namikawa, K., Babaryka, A. and Köster, R. Functional regionalization of the teleost cerebellum analyzed in vivo. Proc Natl Acad Sci USA 111(32): 11846-11851, 2014.
  • Matsui, H., Sato, F., Sato, S., Koike, M., Taruno Y., Saiki, S., Funayama, M., Ito, H., Taniguchi, Y., Uemura N., Toyoda, A., Sakaki, Y., Takeda, S., Uchiyama, Y., Hattori, N. and Takahashi, R. ATP13A2 Deficiency Induces a Decrease in Cathepsin D Activity, Fingerprint-like Inclusion Body Formation and Selective Degeneration of Dopaminergic Neurons. FEBS Lett 587(9): 1316-1325, 2013.
  • Matsui, H., Gavinio, R., Asano T, Uemura N., Ito, H., Taniguchi, Y., Kobayashi Y., Maki, T., Shen J., Hattori, N., Takeda, S., Uemura K., Yamakado H. and Takahashi, R. PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates. Hum Mol Genet 22(12): 2423-2434, 2013.