Feb 12 2025

- Large-scale health checkup data clarified the detailed effects of morbidity in relatives (family history) on the prevalence and onset risk of type 2 diabetes, hypertension, and dyslipidemia -

A research team of visiting researcher IKEDA Izumi, specially appointed associate professor FUJIHARA Kazuya, and professor SONE Hirohito of the Department of Hematology, Endocrinology, and Metabolism, Graduate School of Medical and Dental Sciences, Niigata University, conducted cross-sectional and longitudinal analyses on approximately 40,000 people who underwent medical checkups to quantitatively determine the impact of detailed family histories (disease occurrence in relatives) of typical lifestyle-related diseases such as type 2 diabetes, hypertension, and dyslipidemia on the prevalence and onset risk of each disease.
The results of this research were published in Mayo Clinic Proceedings, an international academic journal, on January 29, 2025.

Key points

• We investigated the effects of family histories in detail on type 2 diabetes, hypertension, and dyslipidemia, using large-scale medical checkup data.
• ​​In a cross-sectional analysis, people with some family history had a 2-3 times higher prevalence risk for all three diseases compared to those without, with the effect being strongest for type 2 diabetes, followed by dyslipidemia and hypertension.
• For all three diseases, the greater the number of affected relatives, the higher the prevalence risk rose. This tendency was particularly pronounced for type 2 diabetes compared to the other two diseases. The prevalence risk was approximately 6 times higher for those with two affected relatives (approximately 3 times higher for the other two diseases), approximately 12 times higher for those with three or more affected relatives (approximately 4 times higher for the other two diseases), and approximately 20 times higher for those with a family history spanning three generations.
• Both family history and obesity additively increased the prevalence risk of each disease. In particular, the risk of hypertension in obese people with a family history of hypertension and a BMI of 30.0 kg/m² or higher was approximately 19 times higher than that of people with no family history and a normal BMI (5-24.9 kg/m²).
• A comparison of onset risks using longitudinal analysis revealed that type 2 diabetes is more strongly influenced by family history than the other two diseases.

Publication Details

Journal: Mayo Clinic Proceedings
Title: Cross-sectional and Longitudinal Associations Between Family History of Type 2 Diabetes Mellitus, Hypertension, and Dyslipidemia and Their Prevalence and Incidence: Toranomon Health Management Center Study (TOPICS24)
Authors: Izumi Ikeda, Risa Igarashi, Kazuya Fujihara, Yasunaga Takeda, Efrem dÁvila Ferreira, Khin Lay Mon, Satoru Kodama, Yasumichi Mori, Takashi Kadowaki, Ritsuko Honda, Yasuji Arase, Hirohito Sone
Doi: 10.1016/j.mayocp.2024.10.020