A diagnostic marker of Stevens-Johnson syndrome / toxic epidermal necrolysis: Identification of galectin-7 by targeted proteomics
May 23, 2019
A team of researchers at Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, led by Professor Riichiro Abe and Assistant Professor Natsumi Hama identified, in collaboration with researchers at Department of Dermatology of Hokkaido University and other institutions, galectin-7 as a new diagnostic marker of Stevens-Johnson syndrome and toxic epidermal necrolysis, both of which are severe drug eruptions. This is expected to help make an early diagnosis of these severe skin reactions possible, potentially promoting the understanding of the pathogenesis of severe drug eruptions that have remained unknown to date.
Publication Details
Title: Galectin-7 as a potential biomarker of Stevens–Johnson syndrome/ toxic epidermal necrolysis: Identification by targeted proteomics using causative drug-exposed peripheral blood cells
Journal: The Journal of Allergy and Clinical Immunology: In Practice
Authors: Natsumi Hama, Keiko Nishimura, Akito Hasegawa, Akihiko Yuki, Hideaki Kume, Jun Adachi, Manao Kinoshita, Youichi Ogawa, Saeko Nakajima, Takashi Nomura, Hideaki Watanabe, Yoshiko Mizukawa, Takeshi Tomonaga, Hiroshi Shimizu, Riichiro Abe
DOI: 10.1016/j.jaip.2019.05.002
More News
-
Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice.
Research results
-
A newly discovered kofun (ancient Japanese burial mound) on a forested hillslope in the Kamigiri of Nagaoka City via topographical surveying using an uncrewed aerial vehicle (UAV)
Research results
-
A Key Factor in Soybean Epigenetics — Soybean DDM1 Regulates Both Transposons and Genes —
Research results
-
Copper imbalance linked to white matter development and social behavior in autism－Study identifies a copper-HIF1α-BNIP3-mTOR pathway connecting trace elements to glial cell development－
Research results