Elucidation of the anti-inflammatory mechanism of erythromycin mediated by DEL-1: Establishment of the therapeutic effect of erythromycin on pneumonia and periodontitis
August 07, 2020
A global study conducted by researchers at the Niigata University Graduate School of Medical and Dental Sciences including Associate Professor Tomoki Maekawa (also a research professor at the Institute for Research Promotion) and Professor Takeyasu Maeda of the Center for Advanced Oral Science, Professor Yutaka Terao of the Division of Microbiology and Infectious Diseases, and Professor Koichi Tabeta of the Division of Periodontology, in collaboration with the Kyoto Pharmaceutical University, the University of Pennsylvania in the US, and the Technical University of Dresden in Germany, revealed that the macrolide antibiotic erythromycin exhibited anti-inflammatory activity against pneumonia and periodontitis by inducing DEL-1.
Publication Details
Title: Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1
Journal: JCI Insight
Authors: Tomoki Maekawa, Hikaru Tamura, Hisanori Domon, Takumi Hiyoshi, Toshihito Isono, Daisuke Yonezawa, Naoki Hayashi, Naoki Takahashi, Koichi Tabeta, Takeyasu Maeda, Masataka Oda, Athanasios Ziogas, Vasileia I. Alexaki, Triantafyllos Chavakis, Yutaka Terao and George Hajishengallis
DOI: 10.1172/jci.insight.136706
More News
-
Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice.
Research results
-
A newly discovered kofun (ancient Japanese burial mound) on a forested hillslope in the Kamigiri of Nagaoka City via topographical surveying using an uncrewed aerial vehicle (UAV)
Research results
-
A Key Factor in Soybean Epigenetics — Soybean DDM1 Regulates Both Transposons and Genes —
Research results
-
Copper imbalance linked to white matter development and social behavior in autism－Study identifies a copper-HIF1α-BNIP3-mTOR pathway connecting trace elements to glial cell development－
Research results