Elucidation of the anti-inflammatory mechanism of erythromycin mediated by DEL-1: Establishment of the therapeutic effect of erythromycin on pneumonia and periodontitis
August 07, 2020
A global study conducted by researchers at the Niigata University Graduate School of Medical and Dental Sciences including Associate Professor Tomoki Maekawa (also a research professor at the Institute for Research Promotion) and Professor Takeyasu Maeda of the Center for Advanced Oral Science, Professor Yutaka Terao of the Division of Microbiology and Infectious Diseases, and Professor Koichi Tabeta of the Division of Periodontology, in collaboration with the Kyoto Pharmaceutical University, the University of Pennsylvania in the US, and the Technical University of Dresden in Germany, revealed that the macrolide antibiotic erythromycin exhibited anti-inflammatory activity against pneumonia and periodontitis by inducing DEL-1.
Publication Details
Title: Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1
Journal: JCI Insight
Authors: Tomoki Maekawa, Hikaru Tamura, Hisanori Domon, Takumi Hiyoshi, Toshihito Isono, Daisuke Yonezawa, Naoki Hayashi, Naoki Takahashi, Koichi Tabeta, Takeyasu Maeda, Masataka Oda, Athanasios Ziogas, Vasileia I. Alexaki, Triantafyllos Chavakis, Yutaka Terao and George Hajishengallis
DOI: 10.1172/jci.insight.136706
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