Nov 18 2020
Associate Professor Tomoyuki Fukuda and Professor Tomotake Kanki of the Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences have demonstrated that a mitochondrial protein called Atg43 promotes mitochondrial degradation through autophagy (mitophagy). Mitophagy maintains cellular integrity by degrading dysfunctional mitochondria. The results of the present study should help elucidate a part of the molecular mechanism of mitophagy and its roles in cells and lead to the prevention and treatment of various diseases caused by mitochondrial dysfunction.
Title: Atg43 tethers isolation membranes to mitochondria to promote starvation-induced mitophagy in fission yeast
Journal: eLife
Authors: Tomoyuki Fukuda, Yuki Ebi, Tetsu Saigusa, Kentaro Furukawa, Shun-ichi Yamashita, Keiichi Inoue, Daiki Kobayashi, Yutaka Yoshida, Tomotake Kanki
DOI: 10.7554/eLife.61245
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