Elucidating a key mechanism underlying cancer invasion/metastasis: Discovery of a unique hydroxylase “PLOD2” essential to the functional activation of integrin on cancer cells.
February 14, 2020
Associate Prof. Ken Saito, Prof. Eisaku Kondo, and their research group at the Division of Molecular and Cellular Pathology, Niigata University Graduate School of Medical and Dental Sciences, elucidated a novel activation mechanism of Integrin, which was regulated by “PLOD2”, a hydroxylase, in collaboration with Dr. Ueki, Prof. Horii (Department of Otolaryngology, Head and Neck Surgery, Niigata Univ.) and Prof. Sakaguchi (Department of Cell Biology, Okayama Univ.). They found the specific interaction between these molecules was revealed to be essential to cancer metastasis via functional activation of Integrin. This discovery is expected to be an important clue for developing a novel advanced tumor therapeutics by suppression of cancer metastasis.
Publication Details
Title: PLOD2 Is Essential to Functional Activation of Integrin β1 for Invasion/Metastasis in Head and Neck Squamous Cell Carcinomas
Journal: iScience
Authors: Yushi Ueki, Ken Saito*, Hidekazu Iioka, Izumi Sakamoto, Yasuhiro Kanda, Masakiyo Sakaguchi, Arata Horii, Eisaku Kondo*
*: corresponding authors
DOI: 10.1016/j.isci.2020.100850
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